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In addition, the current clinical studies on FMT generally have problems such as short follow-up time and lack of systematic research on potential confounding factors in the microbiome, which makes the persistence and repeatability of positive clinical reactions controversial

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It was reported that the serotonin was increased in NSAID-treated mice (Whitfield-Cargile et al., 2016), and the increased serotonin could enhance the intestinal motility which could deteriorate small bowel injuries induced by NSAIDs (Satoh et al., 2009

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